{"id":421,"date":"2019-02-17T23:07:29","date_gmt":"2019-02-17T22:07:29","guid":{"rendered":"https:\/\/bogenommedicinskcannabis.dk\/?page_id=421"},"modified":"2019-02-20T16:10:45","modified_gmt":"2019-02-20T15:10:45","slug":"medicinsk-cannabis-undersoeges-for-effekten-paa-kraeft","status":"publish","type":"page","link":"https:\/\/bogenommedicinskcannabis.dk\/index.php\/artikler\/medicinsk-cannabis-og-kraeft\/medicinsk-cannabis-undersoeges-for-effekten-paa-kraeft\/","title":{"rendered":"Medicinsk cannabis unders\u00f8ges for effekten p\u00e5 kr\u00e6ft"},"content":{"rendered":"

Adskillige andre forskere har efterspurgt yderligere udforskning af cannabis-baserede terapier mod hjernekr\u00e6ft.[1]<\/a> Selvom det er enkeltst\u00e5ende tilf\u00e6lde, er det alligevel interessant, at en separat case rapport publiceret i 2011 i tidsskriftet International Society for Pediatric Neurosurgery<\/em>, dokumenterede en spontan regression af hjernetumorer hos 2 b\u00f8rn, som fik cannabis.[2]<\/a><\/p>\n

Andre separate pr\u00e6-kliniske studier af cannabinoidernes evne til at h\u00e6mme glioma celler viser, at cannabinoider og endocannabinoider ogs\u00e5 kan h\u00e6mme delingen af forskellige andre kr\u00e6ftcelle linier, herunder bl.a. brystkr\u00e6ft,[3]<\/a>prostatakr\u00e6ft,[4]<\/a>kolorektal kr\u00e6ft,[5]<\/a>mavekr\u00e6ft,[6]<\/a> hudkr\u00e6ft,[7]<\/a> leuk\u00e6mi,[8]<\/a>neuroblastoma,[9]<\/a> lungekr\u00e6ft,[10]<\/a> livmoderkr\u00e6ft,[11]<\/a>kr\u00e6ft i skjoldbruskkirtlen,[12]<\/a> bugspytkirtelkr\u00e6ft,[13]<\/a>livmoderhalskr\u00e6ft,[14]<\/a> hoved-halskr\u00e6ft,[15]<\/a> galdegangskr\u00e6ft,[16]<\/a> og lymfomer[17]<\/a><\/p>\n

I nogle tilf\u00e6lde forbedredes den kr\u00e6fth\u00e6mmende aktivitet, n\u00e5r cannabinoiderne blev givet sammen med hinanden snarere end hver for sig.[18]<\/a><\/p>\n

\"\"<\/p>\n

En rapport publiceret i Case Reports in Oncology<\/em>\u00a0 i 2013 fortalte om en succesfuld behandling med cannabis ekstrakt til en 14 \u00e5r gammel patient med en aggressiv form for akut lymfocytisk leuk\u00e6mi.[19]<\/a> Populationsstudier viser ligeledes lovende resultater af brugen af cannabis og forekomsten af forskellige typer kr\u00e6ft, herunder lungekr\u00e6ft,[20]<\/a> hoved-halskr\u00e6ft[21]<\/a> og bl\u00e6rekr\u00e6ft.[22]<\/a><\/p>\n

Som en konsekvens heraf anerkender nogle eksperter, at der eksisterer \u201csolid videnskabelig evidens, som st\u00f8tter, at cannabinoider ud\u00f8ver en bem\u00e6rkelsesv\u00e6rdig kr\u00e6fth\u00e6mmende aktivitet i pr\u00e6-kliniske kr\u00e6ftfors\u00f8g,\u201d[23]<\/a> og mener, at cannabinoider m\u00e5ske en dag vil \u201drepr\u00e6sentere en ny klasse af kr\u00e6fth\u00e6mmende medicin, som sv\u00e6kker kr\u00e6ftv\u00e6kst, h\u00e6mmer angiogenese og spredning af metastaser.[24]<\/a><\/p>\n

\n

[1]<\/a> Parolaro and Massi. 2008. Cannabinoids as a potential new drug therapy for the treatment of gliomas<\/a>. Expert Reviews of Neurotherapeutics<\/em> 8: 37-49
\nGalanti et al. 2007. Delta9-Tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells<\/a>. Acta Oncologica<\/em> 12: 1-9.
\nCalatozzolo et al. 2007. Expression of cannabinoid receptors and neurotrophins in human gliomas<\/a>. Neurological Sciences<\/em> 28: 304-310.
\n[2]<\/a> Foroughi et al. 2011. Spontaneous regression of septum pellucidum\/forniceal pilocytic astrocytomas — possible role of cannabis inhalation. Child’s Nervous System <\/em>27: 671-679.
\n[3]<\/a> Cafferal et al. 2006. Delta-9-Tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation<\/a>. Cancer Research<\/em> 66: 6615-6621.
\nDi Marzo et al. 2006. Anti-tumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma<\/a>. Journal of Pharmacology and Experimental Therapeutics Fast Forward<\/em> 318: 1375-1387.
\nDe Petrocellis et al. 1998. The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation<\/a>. Proceedings of the National Academy of Sciences of the United States of America<\/em> 95: 8375-8380.
\nMcAllister et al. 2007. Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells<\/a>. Molecular Cancer Therapeutics<\/em> 6: 2921-2927.
\nCafferal et al. 2010. Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition<\/a>. Molecular Cancer<\/em> 9: 196.
\n[4]<\/a> Sarfaraz et al. 2005. Cannabinoid receptors as a novel target for the treatment of prostate cancer<\/a>. Cancer Research<\/em> 65: 1635-1641.
\nMimeault et al. 2003. Anti-proliferative and apoptotic effects of anandamide in human prostatic cancer cell lines<\/a>. Prostate<\/em> 56: 1-12.
\nRuiz et al. 1999. Delta-9-tetrahydrocannabinol induces apoptosis in human prostate PC-3 cells via a receptor-independent mechanism<\/a>. FEBS Letters<\/em> 458: 400-404.
\nRamos and Bianco. 2012. The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications<\/a>. Journal of Urology<\/em> 28: 9-14.
\nDePetrocellis et al. 2013. Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms. British Journal of Pharmacology<\/em> 168: 79-102.
\n[5]<\/a> Pastos et al. 2005. The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase-2<\/a>. Gut<\/em> 54: 1741-1750.
\nAviello et al. 2012. Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer<\/a>. Journal of Molecular Medicine<\/em> [E-pub ahead of print]
\n[6]<\/a> Di Marzo et al. 2006. Anti-tumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma<\/a>. Journal of Pharmacology and Experimental Therapeutics Fast Forward<\/em> 318: 1375-1387
\n[7]<\/a> Casanova et al. Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors<\/a>. 2003. Journal of Clinical Investigation<\/em> 111: 43-50
\n[8]<\/a> Powles et al. 2005. Cannabis-induced cytotoxicity in leukemic cell lines<\/a>. Blood<\/em> 105: 1214-1221
\nJia et al 2006. Delta-9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemic T cells in regulated by translocation of Bad to mitochondria<\/a>. Molecular Cancer Research<\/em> 4: 549-562.
\nLiu et al. 2008. Enhancing the in vitro cytotoxic activity of \u00c49-tetrahydrocannabinol in leukemic cells through a combinatorial approach<\/a>. Leukemia and Lymphoma <\/em>49: 1800-1809.
\nScott et al. 2013. Enhancing the activity of cannabidiol and other cannabinoids in vitro through modifications to drug combinations and treatment schedules<\/a> 33: 4373-4380.
\nKampa-Schittenhelm et al. 2016. Dronabinol has preferential antileukemic activity in acute lymphoblastic and myeloid leukemia with lymphoid differentiation patterns. BMC Cancer<\/em>. Open access at: http:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/s12885-015-2029-8<\/a>.
\n[9]<\/a> Manuel Guzman. 2003. Cannabinoids: potential anticancer agents (PDF)<\/a>. Nature Reviews Cancer<\/em> 3: 745-755.
\nMarcu et al. 2010. Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival<\/a>. Molecular Cancer Therapeutics<\/em> 9: 180-189.
\n[10]<\/a> Guzman et al. 2003. Inhibition of tumor angiogenesis by cannabinoids<\/a>. The FASEB Journal<\/em> 17: 529-531
\nPreet et al. 2008. Delta9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo<\/a>. Oncogene<\/em> 10: 339-346.
\n[11]<\/a> Manuel Guzman. 2003. Cannabinoids: potential anticancer agents (PDF)<\/a>. Nature Reviews Cancer<\/em> 3: 745-755.
\n[12]<\/a> Baek et al. 1998. Antitumor activity of cannabigerol against human oral epitheloid carcinoma cells. Archives of Pharmacal Research<\/em>: 21: 353-356.
\n[13]<\/a> Carracedo et al. 2006. Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes<\/a>. Cancer Research<\/em> 66: 6748-6755.
\nMichalski et al. 2008. Cannabinoids in pancreatic cancer: correlation with survival and pain<\/a>. International Journal of Cancer<\/em> 122: 742-750.
\n[14]<\/a> Ramer and Hinz. 2008. Inhibition of cancer cell invasion by cannabinoids via increased cell expression of tissue inhibitor of matrix metalloproteinases-1<\/a>. Journal of the National Cancer Institute<\/em> 100: 59-69.
\nSindiswa and Motadi. 2016. Cannabidiol rather than cannabis sativa extracts inhibit cell growth and induce apoptosis in cervical cancer cells<\/a>. BMC Complimentary and Alternative Medicine <\/em>16: 336.
\n[15]<\/a> Whyte et al. 2010. Cannabinoids inhibit cellular respiration of human oral cancer cells<\/a>. Pharmacology<\/em> 85: 328-335.
\n[16]<\/a> Leelawat et al. 2010. The dual effects of delta(9)-tetrahydrocannabinol on cholangiocarcinoma cells: anti-invasion activity at low concentration and apoptosis induction at high concentration<\/a>. Cancer Investigation<\/em> 28: 357-363.
\n[17]<\/a> Gustafsson et al. 2006. Cannabinoid receptor-mediated apoptosis induced by R(+)-methanandamide and Win55,212 is associated with ceramide accumulation and p38 activation in mantle cell lymphoma<\/a>. Molecular Pharmacology<\/em> 70: 1612-1620.
\nGustafsson et al. 2008. Expression of cannabinoid receptors type 1 and type 2 in non-Hodgkin lymphoma: Growth inhibition by receptor activation<\/a>. International Journal of Cancer<\/em> 123: 1025-1033.
\n[18]<\/a> Torres et al. 2011. A combined preclinical therapy of cannabinoids and Temozolomide against glioma<\/a>. Molecular Cannabis Therapeutics<\/em> 10: 90.
\nScott et al. 2013. Enhancing the activity of cannabidiol and other cannabinoids in vitro through modifications to drug combinations and treatment schedules<\/a> 33: 4373-4380.
\n[19]<\/a> Singh and Bali. 2013. Cannabis extract treatment for terminal acute lymphoblastic leukemia<\/a>. Case Reports in Oncology<\/em> 6: 585-592.
\n[20]<\/a> Washington Post. May 26, 2006. “Study finds no cancer-marijuana connection<\/a>.”
\n[21]<\/a> Liang et al. 2009. A population-based case-control study of marijuana use and head and neck squamous cell carcinoma<\/a>. Cancer Prevention Research<\/em> 2: 759-768.
\n[22]<\/a> Thomas et al. 2015. Association between cannabis use and the risk of bladder cancer: Results from the California Men’s Health Study<\/a>. Urology<\/em> 85: 388-393.
\n[23]<\/a> Velasco et al. 2015. The use of cannabinoids as anticancer agents. Progress in Neuro-Psychopharmacology and Biological Chemistry<\/a>. In print.
\n[24]<\/a> Natalya Kogan. 2005. Cannabinoids and cancer<\/a>. Mini-Reviews in Medicinal Chemistry<\/em> 5: 941-952.
\nSarafaraz et al. 2008. Cannabinoids for cancer treatment: progress and promise<\/a>. Cancer Research<\/em> 68: 339-342.
\nIvanov VN<\/a>1<\/sup>,\u00a0Wu J<\/a>1<\/sup>,\u00a0Hei TK: Regulation of human glioblastoma cell death by combined treatment of cannabidiol, \u03b3-radiation and small molecule inhibitors of cell signaling pathways.
\nOncotarget.<\/a>\u00a02017 May 27. doi: 10.18632\/oncotarget.18240. [Epub ahead of print]
\nhttps:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28599319<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Adskillige andre forskere har efterspurgt yderligere udforskning af cannabis-baserede terapier mod hjernekr\u00e6ft.[1] Selvom det er enkeltst\u00e5ende tilf\u00e6lde, er det alligevel interessant, at en separat case rapport publiceret i 2011 i tidsskriftet International Society for Pediatric Neurosurgery, dokumenterede en spontan regression … L\u00e6s resten →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":306,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-421","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/bogenommedicinskcannabis.dk\/index.php\/wp-json\/wp\/v2\/pages\/421","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bogenommedicinskcannabis.dk\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bogenommedicinskcannabis.dk\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bogenommedicinskcannabis.dk\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bogenommedicinskcannabis.dk\/index.php\/wp-json\/wp\/v2\/comments?post=421"}],"version-history":[{"count":3,"href":"https:\/\/bogenommedicinskcannabis.dk\/index.php\/wp-json\/wp\/v2\/pages\/421\/revisions"}],"predecessor-version":[{"id":672,"href":"https:\/\/bogenommedicinskcannabis.dk\/index.php\/wp-json\/wp\/v2\/pages\/421\/revisions\/672"}],"up":[{"embeddable":true,"href":"https:\/\/bogenommedicinskcannabis.dk\/index.php\/wp-json\/wp\/v2\/pages\/306"}],"wp:attachment":[{"href":"https:\/\/bogenommedicinskcannabis.dk\/index.php\/wp-json\/wp\/v2\/media?parent=421"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}